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Description

To accurately sense changes in H 2 O 2 levels both under normoxic and hypoxic conditions, it is plausible that PNECs may limit their response to fluctuating H 2 O 2 concentrations by avoiding the activation of adaptive ROS-scavenging pathways

1999;339((Pt 1)(Pt 1)):110

Excess Cu + /Cu 2+ and Fe 2+ /Fe 3+ promote the production of reactive hydroxyl radicals through the Fenton reaction, leading to permanent modifications of cellular lipids, nucleic acids, and proteins and causing oxidative damage and cell death (155)